Deterioro cognitivo asociado a radioterapia en tumores cerebrales

  1. Pérez Elvira, Rubén
  2. Clavel, María
Revista:
Psicooncología: investigación y clínica biopsicosocial en oncología

ISSN: 1696-7240

Año de publicación: 2011

Volumen: 8

Número: 2-3

Páginas: 255-264

Tipo: Artículo

DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Psicooncología: investigación y clínica biopsicosocial en oncología

Resumen

Introduction: There is limited knowledge about the influence on cognitive functions of the treatments for brain tumors based on radiotherapy function after RT usually occur after a long period of time. (RT). Objective: To review the works conducted in recent years about the effects of RT on cognition in brain tumors. Method: Using EndNote software X5, articles containing �radiotherapy� and �cognition� in its title, keywords, abstracts or main text in the years 2009-2011 were extracted. Also, an extensive search through the references of articles taken was done. Those works that did not reflect the relationship between RT and the development of cognitive impairment or did not focus on brain tumors were disregarded. Results: 14 articles were selected: 7 originals, 6 reviews, and 1 opinion article. The findings focused on three aspects: a) cognitive impairment due to the RT, b) risk factors for cognitive impairment induced by RT c) time from the application of RT to the onset of cognitive impairment. Conclusions: The new studies confirm findings of recent decades, namely that the functions most commonly affected are attention, memory and learning, psychomotor and executive functions; that there are identifiable risk factors for cognitive impairment associated to RT; and that alterations in cognitive

Referencias bibliográficas

  • 1. Asate. Tomores cerebrales. [En línea] 2011 [Acesso 16 de octubre de 2011]. Disponible en: http://www.asate.es/tag/tumores-cerebrales/
  • 2. AECC. Tumores del sistema nervioso central [En línea] 2011 [Acces 10 de octubre de 2011] disponible en https://www.aecc. es/SobreElCancer/CancerPorLocalizacion/Sistemanerviosocentral/Paginas/Incidencia. aspx
  • 3. Lawrence YR, Allen Li X, El Naqa I, Hahn CA, Marks LB, Merchant TE, Dickers AP. Radiation dose-volume effects in the brain. Int. J. Radiation Oncology Bio. Phys 2010: 76: S20-S27. Doi:10.1016/j.ijro-bp.2009.02.091
  • 4. Douw L, Klein M, Fagel S, Van den Heurel J, Taphoorn M, Aaronson NK, et al. Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: Long-term follow-up. Lancet Neurol 2009; 8: 810-8. Doi:10.1016/S1474-4422(09)70204-2
  • 5. Welzel G, Fleckenstein K, Mai SK, Hermann B, Kraus-Tiefenbacher U, Wenz F. Acute neurocognitive impairment during cranial radiation therapy in patients with intracranial tumors. Strahlenther Onkol., 2008 84 (12):647-54. Doi: 10.1007/s00066-008-1830-6
  • 6. Rigal JF, Noal S, Giffard B. Cognitive dysfunction and cancer: Which consequences in terms of disease managment?. Psychooncology 2011, En prensa. Doi-10.1002/pon.1903.
  • 7. Merchant TE, Conklin HM, Wu J, Lustig RH, Xiong X. Late effects of conformal radiation therapy for pediatric patients with low-grade glioma: Prospective evaluation of cognitive, endocrine, and hearing deficits. J Clin Oncol 2009; 27: 3691-7. Doi:10.1200/JCO.2008.21.2738
  • 8. Corn, BW, Wang, M, Fox, S, Michalski, J, Purdy, J, Simpson, J, et al. Health related quality of life and cognitive status in patients with glioblastoma multiforme receiving escalating doses of conformal three dimensional radiation on RTOG 98-03. J Neurooncol 2009; 95: 247-57. Doi:10.1007/s11060-009-9923-3
  • 9. Van den Brent MJ, Wefel JS, Schiff D, Taphoorn MJB, Jaeckle K, Junck L, et al. Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas Lancet Oncol 2011; 12: 583-93. Doi:10.1016/S1470-2045(11)70057-2
  • 10. Jalali R, Mallick I, Dutta D, Garwami S, Gupta T, Munshi A, Deshpande D, Sarin R. Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereostactic conformal radiotherapy. Int J Rad Oncol Biol Phys 2010; 77; 974-9. Doi:10.1016/j.ijrobp.2009.06.025
  • 11. Shibamoto Y, Sugie C, Iwata, H. Radiotherapy for metastatic brain tumors. Int J Clin Oncol 2009, 14, 281-8. Doi:10.1007/s10147-009-0915-2
  • 12. Platta CS, Khuntia D, Mehta MP, Suh JH. Current treatment strategies for brain metastasis and complications from therapeutic techniques. A review of current literature. Am J Clin Oncol 2010; 33: 398-407. Doi:10.1097/COC.0b013e318194f744
  • 13. Brown PD, Cerhan JH. Same, better, or worse? Neurocognitive effects of radiotherapy for low-grade gliomas remain unknown. Lancet Neurol 2009, 8, 779-81. Doi:10.1016/S1474-4422(09)70205-4
  • 14. Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG., et al. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 2009; 10: 1037-44. Doi:10.1016/S1470-2045(09)70263-3
  • 15. Hilverda H, Bosma I, Heimans JJ, Postma TJ, Vandertop WP, Slotman BJ, et al. Cognitive functioning in glioblastoma patients during radiotherapy and temozolomide treatment: Initial findings. J Neurooncol 2010, 97: 89-94. Doi:10.1007/s11060-009-9993-2
  • 16. Duffner PK. Risk factors for cognitive decline in children treated for brain tumors. Eur J of Paediatric Neurol. 2010, 106-15. Doi:10.1016/j.ejpn.2009.10.005.
Fuente de los datos: Dialnet