Adaptación del Hopkins Verbal Learning test revised con claves semánticas en población española

Abstract

Introduction: Currently, there is a need for standardized neuropsychological tests to discriminate cognitive affectations in the continuum of Mild Cognitive Impairment (MCI) and in Incipient Alzheimer's Disease (IAD). Objective: The objective of this Doctoral Thesis investigation is to analyze and provide clinical data from an adapted version of the Hopkins Verbal Learning Test-Revised (HVLT-R), which incorporates the recall of immediate and delayed semantic patterns, to evaluate a group of participants without neurocognitive disorder (STN), with MCI and in IAD, belonging to the NEDISA population study. Material and method: The sample is made up of 684 participants, divided into 333 STN (73.10±5.79), 141 DCL (76.81±5.87) and 210 IAD (77.71±6.19). The neuropsychological protocol of the NEDISA study was applied to the participants, which includes the evaluation of explicit episodic memory through the adaptation of the HVLT-R. Results: Highly significant differences with a large effect size were obtained when analyzing and comparing the groups of STN, DCL and IAD participants. Delayed semantic cued recall indices and delayed free recall showed the largest effect sizes (0.69), although delayed semantic cued recall showed the best AUC, with high sensitivity and specificity and high % efficacy when comparing groups. The test reflected high reliability (0.95). The recall indices with deferred semantic cues and delayed free recall showed the largest effect sizes (0.69). Age showed a significant influence on the performance of all the indices, gender showed a significant influence only in recognition, and educational level did not present a significant effect on the test indices. Conclusions: The indices of the adapted version of the HVLT-R discriminate the performance of the STN, DCL and IAD groups, specifically the indices with semantic patterns and delayed free recall.